Lyon to Brussels by train
Direct TGV INOUI trains link Lyon Part-Dieu and Brussels-Midi in about four hours; connecting trips via Paris take longer.

- Typical duration
- Direct trains take 3 hours 45 minutes to 4 hours 26 minutes, usually about 4 hours.
- Frequency
- About six direct TGV INOUI trains a day, from early morning to early evening.
- Changes
- No change needed. Direct TGV INOUI trains run from Lyon Part-Dieu to Bruxelles-Midi / Brussel-Zuid.
- Origin
- Lyon
- Destination
- Brussels
Lyon to Brussels takes about four hours on a direct TGV INOUI Brussels service. Direct journey times range from 3 hours 45 minutes to 4 hours 26 minutes. About six direct trains run each day, from early morning to early evening.
The direct trains leave Lyon Part-Dieu and arrive at Bruxelles-Midi / Brussel-Zuid without a change. Depending on the departure, a TGV INOUI Brussels service may call at Le Creusot TGV, Marne-la-Vallée Chessy, Aéroport Charles de Gaulle 2 TGV and Lille Europe; some also call at TGV Haute-Picardie and Arras. You stay on board at each intermediate stop.
Leaving Lyon
Lyon Part-Dieu is the departure station for this route. It is at 5 Place Charles Béraudier, with Metro B, TCL buses and trams nearby. Rhônexpress also links the station with Lyon Saint-Exupéry Airport. Allow enough time to find your platform and board the train shown on your ticket.
Connecting in Paris
Some connecting itineraries change in Paris. TGV INOUI or OUIGO takes you from Lyon Part-Dieu to Paris Gare de Lyon, followed by Eurostar from Paris Nord to Bruxelles-Midi. Gare de Lyon and Paris Nord are different stations, so allow time for the cross-city transfer and treat it as a station change rather than a same-platform connection.
Eurostar appears on the Paris to Brussels leg of these connections. Its Brussels to Lyon booking route also goes via Paris, so Eurostar is a connecting option rather than the direct Lyon to Brussels train.
Arriving at Brussels-Midi
Direct TGV INOUI Brussels services arrive at Bruxelles-Midi, also called Brussel-Zuid. The station is connected to Brussels by metro, tram and bus. Follow the signs to the station concourse after leaving the platform, then use local transport or walk onward from the station.
Tickets, reservations and passes
For a normal point-to-point journey, book the exact TGV INOUI departure you want. TGV INOUI seats must be booked in advance, and the ticket is tied to that service. OUIGO and Eurostar tickets also have their own reserved service and fare conditions. If you book a connection, make sure the booking covers each leg and leave time to transfer between Gare de Lyon and Paris Nord.
Interrail and Eurail pass holders need a separate seat reservation for the high-speed trains on this route. Reservations are required for TGV services between Lyon and Brussels, and the reservation is separate from the Pass. Interrail lists the fee as €20 to €35 in second class and €30 to €45 in first class. Fees can change, so check the current amount when you book.
How often do trains run?
About six direct TGV INOUI trains run each day. The first leaves Lyon Part-Dieu at around 06:00 and the last at around 19:00. Connections via Paris add more options but take longer. Check the timetable for your travel day.
Where to book
Train tickets
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Train service
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Eurostar runs high-speed trains from London St Pancras to Paris (2 h 16 min), Brussels (1 h 53 min) and Amsterdam; London departures require border checks.
Official website - Check times & prices
Ouigo is SNCF's low-cost high-speed brand, serving over 60 destinations in France and routes in Spain; basic fares include one hand bag and one cabin bag.
Official website - Check times & prices
SNCF operates France's TGV and regional trains. SNCF Connect books domestic and many international journeys, with fares ranging from flexible to non-refundable.
Official website
Where to book
Train service
- Check times & prices
Eurostar runs high-speed trains from London St Pancras to Paris (2 h 16 min), Brussels (1 h 53 min) and Amsterdam; London departures require border checks.
Official website - Check times & prices
Ouigo is SNCF's low-cost high-speed brand, serving over 60 destinations in France and routes in Spain; basic fares include one hand bag and one cabin bag.
Official website - Check times & prices
SNCF operates France's TGV and regional trains. SNCF Connect books domestic and many international journeys, with fares ranging from flexible to non-refundable.
Official website
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Frequently asked questions
Is there a direct train from Lyon to Brussels?
Yes. TGV INOUI Brussels runs direct from Lyon Part-Dieu to Bruxelles-Midi / Brussel-Zuid. No change is needed.
How long does Lyon to Brussels take by train?
Direct journeys take about 4 hours. The fastest takes 3 hours 45 minutes and the slowest 4 hours 26 minutes.
How many direct trains run from Lyon to Brussels?
About six direct TGV INOUI trains run each day, between early morning and early evening.
Which operators run from Lyon to Brussels?
SNCF Voyageurs runs the direct TGV INOUI trains. On connecting trips via Paris, OUIGO can cover Lyon to Paris and Eurostar runs Paris to Brussels.
Do I need a reservation from Lyon to Brussels?
Yes. TGV INOUI, OUIGO and Eurostar use reserved services. Interrail and Eurail Pass holders must buy a separate seat reservation, and its fee is not included in the Pass.
Which stations does the train use?
The direct route starts at Lyon Part-Dieu and ends at Bruxelles-Midi / Brussel-Zuid. Direct trains may call at Le Creusot TGV, Marne-la-Vallée Chessy, Aéroport Charles de Gaulle 2 TGV, Lille Europe, TGV Haute-Picardie or Arras, depending on the departure.