--- title: "Trains from Lyon to Brussels | EveryRail" description: "Direct TGV INOUI trains link Lyon Part-Dieu and Brussels-Midi in about four hours; connecting trips via Paris take longer." image: "https://everyrail.com/api/route-image/lyon-to-brussels/" --- [Home]()[Europe by train]()[France]()Lyon to Brussels by train [Home]()[Europe by train]()[France]()Lyon to Brussels by train **Share** - - [Share on WhatsApp]() - [Share on X]() - [Share on Facebook]() - [Share by email]() **On this page** - [About Lyon to Brussels by train]() - [Where to book]() - [Find places to stay in Brussels]() - [Frequently asked questions]() - [More routes]() [Book now]() Last updated October 2026 # Lyon to Brussels by train Direct TGV INOUI trains link Lyon Part-Dieu and Brussels-Midi in about four hours; connecting trips via Paris take longer. ![Ornate gilded guildhouse facades around a historic square.]() Typical duration Direct trains take 3 hours 45 minutes to 4 hours 26 minutes, usually about 4 hours. Frequency About six direct TGV INOUI trains a day, from early morning to early evening. Changes No change needed. Direct TGV INOUI trains run from Lyon Part-Dieu to Bruxelles-Midi / Brussel-Zuid. Origin [Lyon]() Destination [Brussels]() Countries [France](), [Belgium]() [Lyon]() to [Brussels]() takes about four hours on a direct TGV INOUI Brussels service. Direct journey times range from 3 hours 45 minutes to 4 hours 26 minutes. About six direct trains run each day, from early morning to early evening. The direct trains leave Lyon Part-Dieu and arrive at Bruxelles-Midi / Brussel-Zuid without a change. Depending on the departure, a TGV INOUI Brussels service may call at Le Creusot TGV, Marne-la-Vallée Chessy, Aéroport Charles de Gaulle 2 TGV and Lille Europe; some also call at TGV Haute-Picardie and Arras. You stay on board at each intermediate stop. ## Leaving Lyon Lyon Part-Dieu is the departure station for this route. It is at 5 Place Charles Béraudier, with Metro B, TCL buses and trams nearby. Rhônexpress also links the station with Lyon Saint-Exupéry Airport. Allow enough time to find your platform and board the train shown on your ticket. ## Connecting in Paris Some connecting itineraries change in [Paris](). TGV INOUI or OUIGO takes you from Lyon Part-Dieu to Paris Gare de Lyon, followed by Eurostar from Paris Nord to Bruxelles-Midi. Gare de Lyon and Paris Nord are different stations, so allow time for the cross-city transfer and treat it as a station change rather than a same-platform connection. Eurostar appears on the [Paris to Brussels]() leg of these connections. Its [Brussels to Lyon]() booking route also goes via Paris, so Eurostar is a connecting option rather than the direct Lyon to Brussels train. ## Arriving at Brussels-Midi Direct TGV INOUI Brussels services arrive at Bruxelles-Midi, also called Brussel-Zuid. The station is connected to Brussels by metro, tram and bus. Follow the signs to the station concourse after leaving the platform, then use local transport or walk onward from the station. ## Tickets, reservations and passes For a normal point-to-point journey, book the exact TGV INOUI departure you want. TGV INOUI seats must be booked in advance, and the ticket is tied to that service. OUIGO and Eurostar tickets also have their own reserved service and fare conditions. If you book a connection, make sure the booking covers each leg and leave time to transfer between Gare de Lyon and Paris Nord. Interrail and Eurail pass holders need a separate seat reservation for the high-speed trains on this route. Reservations are required for TGV services between Lyon and Brussels, and the reservation is separate from the Pass. Interrail lists the fee as €20 to €35 in second class and €30 to €45 in first class. Fees can change, so check the current amount when you book. ## How often do trains run? About six direct TGV INOUI trains run each day. The first leaves Lyon Part-Dieu at around 06:00 and the last at around 19:00. Connections via Paris add more options but take longer. Check the timetable for your travel day. ## Where to book ### Train tickets - Omio Omio connects you with over 1,000 transport providers - trains, buses, flights, and more - to simplify your travel planning. [Check times & prices]() - Rail Europe Rail Europe is a leading travel tech company specializing in European train bookings for over 15,000 travel professionals worldwide. - Trainline Trainline sells rail and coach tickets worldwide on behalf of major UK and European transport companies. ### Train service - [Eurostar]() Eurostar runs high-speed trains from London St Pancras to Paris (2 h 16 min), Brussels (1 h 53 min) and Amsterdam; London departures require border checks. [Official website]() [Check times & prices]() - [Ouigo]() Ouigo is SNCF's low-cost high-speed brand, serving over 60 destinations in France and routes in Spain; basic fares include one hand bag and one cabin bag. [Official website]() [Check times & prices]() - [SNCF Voyageurs]() SNCF operates France's TGV and regional trains. SNCF Connect books domestic and many international journeys, with fares ranging from flexible to non-refundable. [Official website]() [Check times & prices]() ## Find places to stay in Brussels [![Bright bedroom with white bedding and a breakfast tray on the bed]()**Browse stays in Brussels**Hotels and apartments via Booking.com]() ## Frequently asked questions ### Is there a direct train from Lyon to Brussels? Yes. TGV INOUI Brussels runs direct from Lyon Part-Dieu to Bruxelles-Midi / Brussel-Zuid. No change is needed. ### How long does Lyon to Brussels take by train? Direct journeys take about 4 hours. The fastest takes 3 hours 45 minutes and the slowest 4 hours 26 minutes. ### How many direct trains run from Lyon to Brussels? About six direct TGV INOUI trains run each day, between early morning and early evening. ### Which operators run from Lyon to Brussels? SNCF Voyageurs runs the direct TGV INOUI trains. On connecting trips via Paris, OUIGO can cover Lyon to Paris and Eurostar runs Paris to Brussels. ### Do I need a reservation from Lyon to Brussels? Yes. TGV INOUI, OUIGO and Eurostar use reserved services. Interrail and Eurail Pass holders must buy a separate seat reservation, and its fee is not included in the Pass. ### Which stations does the train use? The direct route starts at Lyon Part-Dieu and ends at Bruxelles-Midi / Brussel-Zuid. Direct trains may call at Le Creusot TGV, Marne-la-Vallée Chessy, Aéroport Charles de Gaulle 2 TGV, Lille Europe, TGV Haute-Picardie or Arras, depending on the departure. ## More routes [![Ornate guild house facades on Brussels' Grand Place]()Amsterdam to Brussels by trainDirect Eurostar from Amsterdam Centraal in 1h52, or Eurocity Direct from Amsterdam Zuid in just over two hours, up to 16 a day. Fares from €25.]()[![View of Brussels, Belgium]()Antwerp to Brussels by trainAntwerp to Brussels by train takes about 45 minutes on frequent direct SNCB InterCity trains, with a choice of three central Brussels stations.]()[![Deutsche Bahn ICE trains beneath the glass roof of Berlin Hauptbahnhof]()Berlin to Brussels by trainDaytime trains take about 7 to 8 hours with a change, usually in Cologne; European Sleeper runs direct overnight from Berlin Hbf six times a week.]()[![Ornate guild house facades on Brussels' Grand Place]()Bruges to Brussels by trainDirect SNCB trains connect Bruges and Brussels in about an hour, roughly every 30 minutes, with distance-based fares and automatic weekend and age discounts.]()[![Amsterdam canal houses and houseboats illuminated at night]()Brussels to Amsterdam by trainDirect trains link Brussels and Amsterdam: Eurostar reaches Amsterdam Centraal in around 1h52, while Eurocity Direct uses Amsterdam Zuid.]()[![Antwerp Central Station facade with ornate clock and gold detailing]()Brussels to Antwerp by trainBrussels to Antwerp trains take as little as 33 minutes, run every 15 to 30 minutes, and cost €6 to €12 one way.]()[![Deutsche Bahn ICE trains beneath the glass roof of Berlin Hauptbahnhof]()Brussels to Berlin by trainDaytime trains take about 6h39 with one change in Cologne; European Sleeper runs direct overnight to Berlin Hbf six times a week.]()[![Bruges canal view with the belfry tower at dusk]()Brussels to Bruges by trainDirect SNCB trains from Brussels to Bruges take 53 to 60 minutes and run every 15 to 30 minutes; no reservation is needed.]() ```json { "@context": "https://schema.org", "@graph": [ { "@type": "Organization", "@id": "https://everyrail.com/#organization", "name": "EveryRail", "url": "https://everyrail.com/", "logo": { "@type": "ImageObject", "url": "https://everyrail.com/_astro/everyrail-logomark-2026.VJ4vNX1T.webp", "@id": "https://everyrail.com/#organization-logo-1" }, "sameAs": [ "https://www.instagram.com/everyrailtravel/", "https://www.facebook.com/everyrail", "https://www.threads.com/@everyrailtravel" ] }, { "@type": "WebSite", "@id": "https://everyrail.com/#website", "name": "EveryRail", "url": "https://everyrail.com/", "publisher": { "@id": "https://everyrail.com/#organization" }, "inLanguage": "en" }, { "@type": "WebPage", "@id": "https://everyrail.com/trains/lyon-to-brussels/#webpage", "name": "Trains from Lyon to Brussels | EveryRail", "description": "Train travel information for Lyon to Brussels. 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